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Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma

Authors: Rahul Kumar, PhD https://orcid.org/0000-0001-9671-1146, Kyle S. Smith, PhD, Maximilian Deng, MD, Colt Terhune, BA, Giles W. Robinson, MD https://orcid.org/0000-0001-7441-9486, Brent A. Orr, MD, PhD https://orcid.org/0000-0003-0997-4728, Anthony P. Y. Liu, MBBS https://orcid.org/0000-0002-8597-9128, Tong Lin, PhD, Catherine A. Billups, MS https://orcid.org/0000-0003-2819-4946, Murali Chintagumpala, MD, Daniel C. Bowers, MD https://orcid.org/0000-0002-3947-2481, Timothy E. Hassall, MD https://orcid.org/0000-0002-7883-3710, Jordan R. Hansford, MD https://orcid.org/0000-0001-7733-383X, Dong Anh Khuong-Quang, PhD https://orcid.org/0000-0001-6305-7790, John R. Crawford, MD, Anne E. Bendel, MD, Sridharan Gururangan, MD https://orcid.org/0000-0003-0311-7127, Kristin Schroeder, MD, MPH https://orcid.org/0000-0002-6433-6174, Eric Bouffet, MD https://orcid.org/0000-0002-6832-6539, Ute Bartels, MD https://orcid.org/0000-0003-2112-5251, Michael J. Fisher, MD, Richard Cohn, MD, Sonia Partap, MD https://orcid.org/0000-0001-5615-7689, Stewart J. Kellie, MD, Geoffrey McCowage, MD, Arnold C. Paulino, MD, Stefan Rutkowski, MD, Gudrun Fleischhack, MD https://orcid.org/0000-0001-5714-007X, Girish Dhall, MD, Laura J. Klesse, MD, PhD https://orcid.org/0000-0003-1323-7720, Sarah Leary, MD https://orcid.org/0000-0003-0225-6184, Javad Nazarian, PhD, Marcel Kool, PhD, Pieter Wesseling, MD https://orcid.org/0000-0001-5453-5201, Marina Ryzhova, MD https://orcid.org/0000-0001-7206-6365, Olga Zheludkova, MD https://orcid.org/0000-0002-8607-3635, Andrey V. Golanov, MD https://orcid.org/0000-0002-0976-4547, Roger E. McLendon, MD, Roger J. Packer, MD, Christopher Dunham, MD https://orcid.org/0000-0002-6244-0584, Juliette Hukin, MB https://orcid.org/0000-0002-8727-8456, Maryam Fouladi, MD, Claudia C. Faria, MD, Jose Pimentel, MD, Andrew W. Walter, MD https://orcid.org/0000-0001-5653-5686, Nada Jabado, MD, PhD, Yoon-Jae Cho, MD, Sebastien Perreault, MD, Sidney E. Croul, MD, Michal Zapotocky, MD, PhD https://orcid.org/0000-0002-2349-2541, Cynthia Hawkins, MD, PhD https://orcid.org/0000-0003-2618-4402, Uri Tabori, MD https://orcid.org/0000-0002-5019-2683, Michael D. Taylor, MD, PhD, Stefan M. Pfister, MD https://orcid.org/0000-0002-5447-5322, Paul Klimo Jr, MD, Frederick A. Boop, MD, David W. Ellison, MD, PhD, Thomas E. Merchant, DO, PhD https://orcid.org/0000-0002-0412-6255, Arzu Onar-Thomas, PhD, Andrey Korshunov, MD, David T. W. Jones, PhD, Amar Gajjar, MD https://orcid.org/0000-0001-5019-0699, Vijay Ramaswamy, MD, PhD https://orcid.org/0000-0002-6557-895X, and Paul A. Northcott, PhD [email protected]Authors Info & Affiliations
Publication: Journal of Clinical Oncology

Disclaimer

The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data and had the final responsibility to submit for publication.

Support

Supported by American Lebanese Syrian Associated Charities, St Jude Children's Research Hospital; Alexander and Margaret Stewart Trust (P.A.N.); American Association for Cancer Research (P.A.N.); St Baldrick's Foundation (P.A.N.); Alex's Lemonade Stand Young Investigator Award (V.R.); C.R. Younger Foundation (V.R.); Canadian Institutes of Health Research (V.R.); Nelina's Hope and Garron Family Cancer Centre (V.R.).

Information & Authors

Information

Published In

Journal of Clinical Oncology
Pages: 807 - 821
PubMed: 33502920

History

Published online: January 27, 2021
Published in print: March 01, 2021

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Authors

Affiliations

Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN
Graduate School of Biomedical Sciences, St Jude Children's Research Hospital, Memphis, TN
Kyle S. Smith, PhD
Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN
Maximilian Deng, MD
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
Colt Terhune, BA
Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
Department of Pathology, St Jude Children's Research Hospital, Memphis, TN
Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN
Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
Tong Lin, PhD
Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN
Catherine A. Billups, MS https://orcid.org/0000-0003-2819-4946
Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN
Murali Chintagumpala, MD
Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX
Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX
Department of Pediatric Oncology, Lady Ciliento Children's Hospital, South Brisbane, Queensland, Australia
Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Victoria, Australia
Dong Anh Khuong-Quang, PhD https://orcid.org/0000-0001-6305-7790
Department of Haematology and Oncology, Royal Children's Hospital, Parkville, Victoria, Australia
John R. Crawford, MD
Department of Neurosciences and Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, CA
Anne E. Bendel, MD
Department of Hematology-Oncology, Children's Hospital of Minnesota, Minneapolis, MN
Sridharan Gururangan, MD https://orcid.org/0000-0003-0311-7127
Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC
Kristin Schroeder, MD, MPH https://orcid.org/0000-0002-6433-6174
Preston Robert Tisch Brain Tumor Center, Duke University, Durham, NC
Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Michael J. Fisher, MD
Division of Oncology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
Richard Cohn, MD
Kid's Cancer Centre, Sydney Children's Hospital and School of Woman's and Children's Health, Sydney, New South Wales, Australia
Departments of Neurology and Pediatrics, Stanford University, Palo Alto, CA
Stewart J. Kellie, MD
Department of Pediatric Oncology, Children's Hospital at Westmead, Westmead, New South Wales, Australia
Geoffrey McCowage, MD
Department of Pediatric Oncology, Children's Hospital at Westmead, Westmead, New South Wales, Australia
Arnold C. Paulino, MD
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX
Stefan Rutkowski, MD
Department of Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Department of Pediatrics, University Hospital Essen, Essen, Germany
Girish Dhall, MD
Division of Pediatric Hematology/Oncology, Children's Hospital of Los Angeles, Los Angeles, CA
Laura J. Klesse, MD, PhD https://orcid.org/0000-0003-1323-7720
Division of Pediatric Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX
Department of Hematology-Oncology, Seattle Children's Hospital, Seattle, WA
Javad Nazarian, PhD
Research Center for Genetic Medicine, Children's National Health System, Washington, DC
Marcel Kool, PhD
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands
Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia
Department of Neuro-Oncology, Russian Scientific Center of Radiology, Moscow, Russia
Department of Neuroradiology, NN Burdenko Neurosurgical Institute, Moscow, Russia
Roger E. McLendon, MD
Department of Pathology, Duke University Medical Center, Durham, NC
Roger J. Packer, MD
Children's National Hospital, Washington, DC
Department of Pathology and Laboratory Medicine, Division of Anatomical Pathology, BC Children's Hospital, Vancouver, British Columbia, Canada
Department of Pediatrics, Division of Neurology, BC Children's Hospital, Vancouver, British Columbia, Canada
Maryam Fouladi, MD
Department of Pediatrics, Division of Oncology, Cincinnati Children's Hospital, Cincinnati, OH
Claudia C. Faria, MD
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
Jose Pimentel, MD
Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal
Department of Hematology/Oncology, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE
Nada Jabado, MD, PhD
Department of Pediatrics, Research Institute of the McGill University Health Center, Montreal, Québec, Canada
Yoon-Jae Cho, MD
Department of Pediatrics, Pediatric Neurology, Oregon Health & Science University, Portland, OR
Sebastien Perreault, MD
Division of Neurology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Québec, Canada
Sidney E. Croul, MD
Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
Michal Zapotocky, MD, PhD https://orcid.org/0000-0002-2349-2541
Prague Brain Tumor Research Group, Charles University and University Hospital Motol, Prague, Czech Republic
Cynthia Hawkins, MD, PhD https://orcid.org/0000-0003-2618-4402
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Michael D. Taylor, MD, PhD
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia
Paul Klimo Jr, MD
Division of Pediatric Neurosurgery, Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN
Frederick A. Boop, MD
Division of Pediatric Neurosurgery, Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN
David W. Ellison, MD, PhD
Department of Pathology, St Jude Children's Research Hospital, Memphis, TN
Thomas E. Merchant, DO, PhD https://orcid.org/0000-0002-0412-6255
Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN
Arzu Onar-Thomas, PhD
Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN
Andrey Korshunov, MD
Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany
David T. W. Jones, PhD
Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany
Department of Oncology, St Jude Children's Research Hospital, Memphis, TN
Vijay Ramaswamy, MD, PhD https://orcid.org/0000-0002-6557-895X
Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
Paul A. Northcott, PhD [email protected]
Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN
Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany

Notes

Paul A. Northcott, PhD, 262 Danny Thomas Place, MS325, Memphis, TN 38105-3678; e-mail: [email protected].
*
R.K. and K.S.S. contributed equally to this work. D.T.W.J., A.G., V.R., and P.A.N. contributed equally to this work.

Author Contributions

Conception and design: Rahul Kumar, Kyle S. Smith, Giles W. Robinson, David T. W. Jones, Amar Gajjar, Vijay Ramaswamy, Paul A. Northcott
Financial support: David T. W. Jones, Amar Gajjar, Vijay Ramaswamy, Paul A. Northcott
Administrative support: Giles W. Robinson, Amar Gajjar, Paul A. Northcott
Provision of study materials or patients: Giles W. Robinson, Brent A. Orr, Murali Chintagumpala, Daniel C. Bowers, Timothy E. Hassall, Jordan R. Hansford, Dong Anh Khuong-Quang, John R. Crawford, Anne E. Bendel, Sridharan Gururangan, Kristin Schroeder, Eric Bouffet, Ute Bartels, Michael J. Fisher, Richard Cohn, Sonia Partap, Stewart J. Kellie, Geoffrey McCowage, Arnold C. Paulino, Stefan Rutkowski, Gudrun Fleischhack, Girish Dhall, Laura J. Klesse, Sarah Leary, Javad Nazarian, Marcel Kool, Pieter Wesseling, Marina Ryzhova, Olga Zheludkova, Andrey V. Golanov, Roger E. McLendon, Roger J. Packer, Christopher Dunham, Juliette Hukin, Maryam Fouladi, Claudia C. Faria, Jose Pimentel, Andrew W. Walter, Nada Jabado, Yoon-Jae Cho, Sebastien Perreault, Sidney E. Croul, Michal Zapotocky, Cynthia Hawkins, Uri Tabori, Michael D. Taylor, Stefan M. Pfister, Paul Klimo Jr, Frederick A. Boop, David W. Ellison, Thomas E. Merchant, Andrey Korshunov, David T. W. Jones, Amar Gajjar, Vijay Ramaswamy
Collection and assembly of data: Rahul Kumar, Kyle S. Smith, Maximilian Deng, Giles W. Robinson, Brent A. Orr, Colt Terhune, Anthony P. Y. Liu, Tong Lin, Catherine A. Billups, Arzu Onar-Thomas, Andrey Korshunov, David T.W. Jones, Amar Gajjar, Vijay Ramaswamy, Paul A. Northcott
Data analysis and interpretation: Rahul Kumar, Kyle S. Smith, Maximilian Deng, Giles W. Robinson, Brent A. Orr, Anthony P. Y. Liu, Tong Lin, Catherine A. Billups, Arzu Onar-Thomas, Andrey Korshunov, David T. W. Jones, Amar Gajjar, Vijay Ramaswamy, Paul A. Northcott
Manuscript writing: All authors
Final approval of manuscript: All authors
Accountable for all aspects of the work: All authors

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Rahul Kumar, Kyle S. Smith, Maximilian Deng, Colt Terhune, Giles W. Robinson, Brent A. Orr, Anthony P. Y. Liu, Tong Lin, Catherine A. Billups, Murali Chintagumpala, Daniel C. Bowers, Timothy E. Hassall, Jordan R. Hansford, Dong Anh Khuong-Quang, John R. Crawford, Anne E. Bendel, Sridharan Gururangan, Kristin Schroeder, Eric Bouffet, Ute Bartels, Michael J. Fisher, Richard Cohn, Sonia Partap, Stewart J. Kellie, Geoffrey McCowage, Arnold C. Paulino, Stefan Rutkowski, Gudrun Fleischhack, Girish Dhall, Laura J. Klesse, Sarah Leary, Javad Nazarian, Marcel Kool, Pieter Wesseling, Marina Ryzhova, Olga Zheludkova, Andrey V. Golanov, Roger E. McLendon, Roger J. Packer, Christopher Dunham, Juliette Hukin, Maryam Fouladi, Claudia C. Faria, Jose Pimentel, Andrew W. Walter, Nada Jabado, Yoon-Jae Cho, Sebastien Perreault, Sidney E. Croul, Michal Zapotocky, Cynthia Hawkins, Uri Tabori, Michael D. Taylor, Stefan M. Pfister, Paul Klimo, Frederick A. Boop, David W. Ellison, Thomas E. Merchant, Arzu Onar-Thomas, Andrey Korshunov, David T. W. Jones, Amar Gajjar, Vijay Ramaswamy, Paul A. Northcott
Journal of Clinical Oncology 2021 39:7, 807-821

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