Common Estimand Challenges in Oncology
Discussion of strategies.
Example With OS
Example in the Adjuvant Treatment Setting
How the Estimand Framework Helped Design A Study of Chimeric Antigen Receptor T-cell Therapy in Lymphoma
Treatment Strategies to Be Compared
Manufacturing failure in the CAR-T arm or failing to receive ASCT in the SOC arm.
New cancer therapy started before observing EFS event.
Insufficient remission (stable disease or progressive disease) at week 6.
Authors' Disclosures of Potential Conflicts of Interest
Lisa V. Hampson
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JCO Precision Oncology 2019 :3, 1-10