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Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

Authors: Marjanka K. Schmidt [email protected], Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, Muriel A. Adank, Hanne Meijers, Quinten Waisfisz, Antoinette Hollestelle, Mieke Schutte, Ans van den Ouweland, Maartje Hooning, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Antonis C. Antoniou, Volker Arndt, Marina Bermisheva, Natalia V. Bogdanova, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G. Giles, Lothar Haeberle, Per Hall, Peter Hillemanns, John L. Hopper, Anna Jakubowska, Esther M. John, Michael Jones, Elza Khusnutdinova, Julia A. Knight, Veli-Matti Kosma, Vessela Kristensen, Andrew Lee, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Sara Margolin, Alfons Meindl, Roger L. Milne, Taru A. Muranen, Polly A. Newcomb, Kenneth Offit, Tjoung-Won Park-Simon, Julian Peto, Paul D.P. Pharoah, Mark Robson, Anja Rudolph, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Julie Soens, Melissa C. Southey, Amanda B. Spurdle, Harald Surowy, Anthony Swerdlow, Rob A.E.M. Tollenaar, Ian Tomlinson, Amy Trentham-Dietz, Celine Vachon, Qin Wang, Alice S. Whittemore, Argyrios Ziogas, Lizet van der Kolk, Heli Nevanlinna, Thilo Dörk, Stig Bojesen, and Douglas F. EastonAuthors Info & Affiliations
Publication: Journal of Clinical Oncology

Abstract

Purpose

CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.

Patients and Methods

CHEK2*1100delC genotyping was mostly done by a custom Taqman assay. Breast cancer odds ratios (ORs) for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression and adjusted for study (categorical) and age. Main analyses included patients with invasive breast cancer from population- and hospital-based studies.

Results

Proportions of heterozygous CHEK2*1100delC carriers in controls, in patients with breast cancer from population- and hospital-based studies, and in patients with breast cancer from familial- and clinical genetics center–based studies were 0.5%, 1.3%, and 3.0%, respectively. The estimated OR for invasive breast cancer was 2.26 (95%CI, 1.90 to 2.69; P = 2.3 × 10−20). The OR was higher for estrogen receptor (ER)–positive disease (2.55 [95%CI, 2.10 to 3.10; P = 4.9 × 10−21]) than it was for ER-negative disease (1.32 [95%CI, 0.93 to 1.88; P = .12]; P interaction = 9.9 × 10−4). The OR significantly declined with attained age for breast cancer overall (P = .001) and for ER-positive tumors (P = .001). Estimated cumulative risks for development of ER-positive and ER-negative tumors by age 80 in CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom.

Conclusion

These CHEK2*1100delC breast cancer risk estimates provide a basis for incorporating CHEK2*1100delC into breast cancer risk prediction models and into guidelines for intensified screening and follow-up.

Introduction

Susceptibility to breast cancer is known to be conferred by rare mutations in high-risk genes, notably BRCA1 and BRCA2, by mutations in several moderate-risk genes, and by a large number of common genetic variants. Among moderate-risk genes, one of the best established is CHEK2 (cell-cycle checkpoint kinase 2).1 The protein encoded by CHEK2 is a cell-cycle checkpoint regulator and putative tumor suppressor and it plays a critical role in the DNA damage repair pathway.2-4 The 1100delC germline mutation in CHEK2, which is located at 22q12.1 (NM_007194.3(CHEK2):c.1100del: p.(Thr367Metfs*15)), is the most frequently found protein-truncating variant in populations of European descent.1,5-7 Deletion of a single cytosine at position 1100 in exon 10 introduces a stop codon and results in a kinase-dead CHEK2 protein.
Although the evidence that CHEK2*1100delC is associated with increased breast cancer risk is unequivocal, the magnitude of the risk is still uncertain, in part because the variant is relatively uncommon and in part because many studies have oversampled cases with a family history of disease, which leads to biased results. Published relative risk estimates for CHEK2*1100delC carriers vary between 1.5 and 3.7-10 The largest meta-analysis of breast cancer risk for CHEK2*1100delC estimated an odds ratio (OR) of 2.7 (95% CI, 2.1 to 3.4) on the basis of unselected breast cancer cases and an almost two times higher OR on the basis of on familial breast cancer cases (OR, 4.8; 95% CI, 3.3 to 7.2).7 Although CHEK2*1100delC carriers tend to develop estrogen receptor (ER)–positive tumors, they have a worse breast-cancer specific survival compared with noncarriers.8,11-14 CHEK2*1100delC is also associated with a higher risk for contralateral breast cancer.9,11,12,15 We previously showed that, especially in countries with a high prevalence of CHEK2*1100delC, this variant occurred relatively frequently in population-based young patients with breast cancer1,7,11; however, no unbiased age-specific risk estimates have been reported so far for CHEK2*1100delC carriers.
In the last few years, clinical genetic testing of women to estimate future risk of breast cancer has progressed beyond BRCA1 and BRCA2 testing to the use of gene panel testing, which involves the simultaneous testing of many known or suspected susceptibility genes, including CHEK2.16 Such clinical testing, however, need to be underpinned by reliable risk estimates. Moreover, screening and prevention strategies are age dependent and driven by such factors as family planning,17 and, hence, require reliable age-specific risks. In addition, knowledge about subtype-specific risks may be relevant for breast cancer prevention strategies.18 The aim of the current study, therefore, was to provide age- and tumor subtype–specific risk estimates by using data from the Breast Cancer Association Consortium (BCAC), which includes > 85,000 women who have been genotyped for CHEK2*1100delC.

Patients and Methods

Patient and Clinical Data Collection

From 36 studies in the BCAC, 96,489 persons were genotyped for CHEK2*1100delC. After exclusion of non-Europeans and males, 91,147 women from 35 studies remained, including 930 heterozygous and 15 homozygous CHEK2*1100delC carriers (Appendix Table A1, online only; Appendix Fig A1, online only). Two studies in which fewer than three CHEK2*1100delC carriers were detected were excluded from further risk analyses, which left 42,977 controls and 44,777 patients with breast cancer from 33 studies (Appendix Fig A1). Genotype data from five studies had been included in a previous meta-analysis,1 but the majority of data were generated in a new genotyping experiment. Studies were classified according to sampling frame for the cases and controls into population- and hospital-based studies (unselected for family history) or clinical genetics–based and familial studies. Data on patient characteristics—age, family history, and BRCA1/2 mutation status—and tumor characteristics had also been submitted by individual studies and were centrally harmonized and checked according to a standard data dictionary (Data Supplement). Details of the studies have been published previously (Appendix Table A1),19,20 and a subset of the data has been previously used for an analysis of CHEK2*1100delC and disease outcome.12 All studies were approved by the relevant institutional review boards, and participants provided written informed consent or did not object to the secondary use of their tissue and data following country-specific regulations.21

CHEK2*1100delC Genotyping

Details of CHEK2*1100delC genotyping performed in the 35 European studies included are shown in the Data Supplement and in Appendix Table A1. Genotyping of the majority of samples (n = 84,314) was done by using a 5′exonuclease Taqman allelic discrimination assay developed by the Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital. Primers for the custom Taqman assay were specifically designed to be nonbinding to the pseudogenes on chromosomes 15 and 16, which are homologous to exons 10 to 14 of CHEK2 on chromosome 22. An additional 6,833 samples were genotyped by using a different Taqman, iPlex, or oligohybridization assay.

Statistical Analyses

Primary analyses were performed by using STATA (version SE11.2; STATA, College Station, TX; Computing Resource Center, Santa Monica, CA), and calculation of cumulative risks, estimates of frequency by country, and graphics in Figures 1 and 2 were performed in R (version 3.2.1; R Foundation for Statitiscal Computing, Vienna, Austria). P values reported are two-sided, and P values < .05 were considered significant. Differences between proportions were tested by using the Pearson χ2 test, Fisher’s exact test was used for comparisons that included cells with fewer than five observations, and differences and between mean ages were tested by using the t test. Breast cancer ORs for CHEK2*1100delC carriers versus noncarriers were estimated by using logistic regression. All variables were included in analyses as categorical, as indicated in the tables, except for age (continuous in years). All analyses were adjusted for study (categorical). We compared a carrier model—homozygous and heterozygous CHEK2*1100delC carriers were combined—and a log-additive model, including a linear term of the number of 1100delC alleles, with a saturated model by using likelihood ratio tests. Because no homozygous carriers were observed in controls, the saturated model did not converge, and we determined the likelihood by considering a range of possible values for the homozygote risk—between 5 and 20, in 1-point increments—by using an offset term.
Fig 1. CHEK2*1100delC frequency rates per country in legend are shown with 95% confidence intervals and were calculated using a modification of the empirical Bayes approach proposed by Clayton and Kaldor, as described in the methods. Analysis included all controls (44,276 non-carriers and 235 CHEK2*1100delC carriers) and all population- and hospital-based breast cancer patients (38,783 non-carriers and 502 CHEK2*1100delC carriers). When the breast cancer patients from the clinical genetics and familial studies were also included, the rates slightly changed, but not the color of the countries in the map (results not shown).
Fig 2. Breast cancer relative risk curves for CHEK2*1100delC carriers by age for invasive breast cancer: overall, estrogen receptor (ER)–positive, and ER-negative disease. OR, odds ratio.
The main analyses focused on the comparison of patients with breast cancer recruited through population- and hospital-based studies. We performed sensitivity analyses that excluded known BRCA1/2 carriers, in situ and unknown behavior breast cancers, prevalent breast cancers (from patients whose blood was sampled > 1 year after diagnosis), and samples for which CHEK2*1100delC genotypes were obtained with assays other than the custom Taqman. Subgroup case-control analyses were performed by age, family history, and tumor subtype of patients with breast cancer. To assess statistical significance of differences between subgroups, we compared these subgroups in a case-only analysis with CHEK2 as the dependent variable. For the forest plot (Appendix Fig A2, online only), the summary estimate was derived from a fixed effect meta-analysis of the log(OR) estimates from individual studies by using the inverse variance method (fixedi in STATA).
In addition, we modeled the CHEK2*1100delC breast cancer risk estimates by age by using the more stable interaction estimates for age and CHEK2*1100delC from the case-only analysis (Data Supplement). Cumulative risks were calculated on the basis of estimated relative breast cancer risks for CHEK2*1100delC carriers by using United Kingdom breast cancer incidences from 1992 to 2010 and the ratio of ER-positive and ER-negative breast tumors from the BCAC database (Data Supplement). Carrier frequency estimates by country were derived by using a modification of the empirical Bayes approach proposed by Clayton and Kaldor22 for mapping disease incidence rates (Data Supplement).

Results

Analyses included 42,977 controls and 44,777 patients with breast cancer from 33 BCAC studies, of which 42,627 patients were recorded as having invasive tumors as well as 1,734 with in situ tumors (Appendix Fig A1). We included in the analysis only European women who had been genotyped for CHEK2*1100delC because this mutation is rare in other ethnicities23; we detected only three carriers of the mutation in non-Europeans. Summaries of patient and tumor characteristics by study are shown in Appendix Tables A2 to A6 (online only), and characteristics of CHEK2*1100delC carriers and noncarriers are summarized in Appendix Table A7 (online only).

CHEK2*1100delC Heterozygous and Homozygous Carriers

Proportions of CHEK2*1100delC carriers in controls, patients with breast cancer from population- or hospital-based studies, and patients from familial or clinical genetics center–based studies were 0.5%, 1.3%, and 3.0% respectively (Appendix Table A7). Homozygous CHEK2*1100delC carriers were rare (n = 15; 0.02%) and occurred only in cases. Ten of 15 homozygous carriers were identified in studies from the Netherlands (Appendix Table A1, online only). The frequency of CHEK2*1100delC in women of European descent displayed wide variation by country, from > 1.2% in the Netherlands and Finland to < 0.3% in Eastern Europe (Fig 1).
Comparison of a carrier model in which both homozygous and heterozygous CHEK2*1100delC were defined as carriers, with a saturated model (see Patients and Methods) indicated a higher risk estimate for homozygous than heterozygous carriers (P = .017 on the basis of population- and hospital-based studies; Appendix Table A8, online only). A log-additive model could not be rejected (P = .10 compared with the saturated model); however, the estimated ORs for heterozygotes were similar in the three models. Because homozygous carriers were rare and it would not be possible to obtain reliable estimates for age- and tumor subtype–specific analyses, we excluded the 15 homozygous carriers so that subsequent risk estimates refer to heterozygous carriers.

Tumor Characteristics of CHEK2*1100delC Carriers

CHEK2*1100delC patients with breast cancer from population- and hospital-based studies were younger and more often developed ER-positive and progesterone receptor (PR)–positive tumors, although carriers and non-carriers were similar with respect to morphology, grade, and human epithelial growth factor receptor 2 (HER2) status (Table 1); results for the clinical genetic and familial studies were similar. CHEK2*1100delC patients with breast cancer from population- and hospital-based studies more often developed in situ tumors. We suspected that the association between CHEK2*1100delC and in situ tumors could be a result of differential recruitment related to family history of breast cancer and screening. In support of this hypothesis, there was evidence of an association between CHEK2*1100delC and first-degree family history of breast cancer for women with in situ cancers (P = .05), but not for invasive tumors (P = .85; using logistic regression analysis adjusted for study). No such associations were observed for patients with breast cancer in clinical genetic and familial studies. In controls, there was no association between CHEK2*1100delC carriership and family history (n = 41,529; OR, 1.00; 95% CI, 1.00 to 1.00; P = .77) or age (n = 38,358; OR, 1.00; 95% CI, 0.99 to 1.01; P = .99).
Table 1. Associations of Patient and Tumor Characteristics With CHEK2*1100delC Carriership in Patients With Breast Cancer
CharacteristicPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
Total, No.OR95% CIPTotal, No.OR95% CIP
Family history*37,9131.001.00 to 1.00.446,84911.00 to 1.00.43
Age, years37,5660.990.98 to 0.991.0 × 10−36,8340.990.98 to 1.01.37
Tumor behavior37,5711.651.11 to 2.44.016,7750.680.35 to 1.32.25
Morphology30,729   4,831   
 Ductal Ref   Ref  
 Lobular 0.910.68 to 1.22.52 0.450.23 to 0.90.02
 Medullary 0.690.25 to 1.88.46 Omitted  
 Mixed 1.170.69 to 2.00.56 1.370.59 to 3.21.47
 Mucinous 1.020.42 to 2.48.97 Omitted  
 Other 0.790.42 to 1.51.48 0.690.39 to 1.22.20
 Papillary 0.830.11 to 6.02.85 Omitted  
 Tubular 0.230.03 to 1.63.14 1.140.45 to 2.87.79
Grade25,808   3,070   
 I Ref   Ref  
 II 1.320.99 to 1.77.06 1.350.77 to 2.36.30
 III 1.130.82 to 1.55.46 1.030.57 to 1.87.91
ER status26,103   2,532   
 Negative Ref   Ref  
 Positive 1.921.42 to 2.612.7 × 10−5 2.361.24 to 4.48.01
PR status21,687   2,372   
 Negative Ref   Ref  
 Positive 1.371.06 to 1.77.02 1.580.95 to 2.63.08
HER2 status12,687   655   
 Negative Ref   Ref  
 Positive 1.030.69 to 1.52.90 0.690.24 to 2.01.50
NOTE. Data given are those included in analyses for each model (Appendix Tables A2 to A5). Homozygous carriers were excluded. Analyses were performed by logistic regression with CHEK2 as the dependent variable and adjusted for study. For BRCA1/2 mutation status there was insufficient data for the models to run.
Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; OR, odds ratio; PR, progesterone receptor; Ref, reference category.
*
Family history: yes, at least one first-degree relative with breast cancer; or no, none.

Overall Breast Cancer Risk Estimates and Sensitivity Analyses

Breast cancer risk estimates for CHEK2*1100delC carriers, including various sensitivity analyses, are shown in Table 2. ORs for breast cancer of any behavior (in situ or invasive) and invasive breast cancer were 2.32 (95%CI, 1.95 to 2.75; P = 5.5 × 10−22) and 2.26 (95% CI, 1.90 to 2.69; P = 2.3 × 10−20), respectively, using population- and hospital-based studies. There was no evidence of heterogeneity in ORs among the studies (Appendix Fig A2). The OR based on all breast cancers, including those from familial and clinical genetics center-based studies, was higher (OR = 2.44; 95% CI, 2.08 to 2.87; P = 6.3 × 10−28), consistent with overrepresentation of cases with a family history of disease. The OR based on incident breast cancers only was lower (OR = 2.11; 95% CI, 1.69 to 2.65; P = 6.3 × 10−11); in case-only analysis this was significantly different from the OR for prevalent tumors (P = 1.5 × 10−4).
Table 2. Breast Cancer Relative Risk Estimates for CHEK2*1100delC Carriers Versus Noncarriers; Tumor Behavior Subgroup and Sensitivity Analyses
SubgroupCase/Control, No.OR95% CIP
All patients with breast cancer41,744/39,9562.442.08 to 2.876.3 × 10−28
Population- and hospital-based patients with breast cancer36,029/39,4642.321.95 to 2.755.5 × 10−22
All invasive tumors39,798/39,9562.402.04 to 2.822.0 × 10−26
Population- and hospital-based patients with breast cancer, invasive tumors34,525/36,4642.261.90 to 2.692.3 × 10−20
Population- and hospital-based patients with breast cancer, invasive tumors, incident breast cancers only*16,702/28,7722.111.69 to 2.656.3 × 10−11
All in situ tumors1,577/34,8183.532.38 to 5.233.9 × 10−10
Population- and hospital-based patients with breast cancer, in situ tumors1,208/33,3793.362.15 to 5.251.0 × 10−7
All patients with breast cancer, custom Taqman39,440/36,5962.502.11 to 2.951.2 × 10−26
Population- and hospital-based patients with breast cancer, custom Taqman34,485/34,4662.331.96 to 2.795.5 × 10−21
All patients with breast cancer, non-BRCA1/2 carriers only41,365/39,9542.462.09 to 2.882.7 × 10−28
Population- and hospital-based patients with breast cancer, non-BRCA1/2 carriers only35,872/36,4622.331.96 to 2.764.0 × 10−22
NOTE. All models were adjusted for age and study.
Abbreviation: OR, odds ratio.
*
Incident breast cancer was defined as study entry before and up to 1 year after breast cancer diagnosis.
Likely biased estimate (see text).

Subgroup Breast Cancer Risk Estimates

Table 3 gives breast cancer risk estimates for CHEK2*1100delC carriers by patient subgroup and by tumor subtype. The OR was higher for women without a first-degree relative with breast cancer compared with those with a family history, but not significantly so (P = .31). Moreover, this analysis included two studies with outlier results that were caused by the study definitions that were used (Appendix Table A6). Excluding these two studies, ORs for women without and with a first-degree relative with breast cancer were similar: 2.33 (95% CI, 1.76 to 3.08) and 2.26 (95% CI, 1.84 to 2.77), respectively. CHEK2*1100delC carriers had a significantly higher risk compared with noncarriers of developing an ER-positive versus an ER-negative tumor (P = 9.9 × 10−6), with an OR of 2.55 (95% CI, 2.10 to 3.10; P = 4.9 × 10−21) versus an OR of 1.32 (95% CI, 0.93 to 1.88; P = .12;), respectively. Associations with PR status were similar to those for ER, but the OR for PR-negative tumors was higher than that for ER-negative tumors. In the case-only analysis, there was no association with PR status after adjusting for ER status (P = .84), whereas CHEK2*1100delC was still associated with ER status after adjustment for PR (P = 2.1 × 10−4). There was no association with HER2 status (P = .73; P = .32 after adjustment for ER).
Table 3. Breast Cancer Relative Risk Estimates for CHEK2*1100delC Carriers Versus Noncarriers by Subgroup in Population- and Hospital-Based Patients With Breast Cancer With Invasive Tumors
SubgroupTotal in Case-Control Analysis, No.OR95% CIP Case-Control AnalysisP Case-Only Analysis
Family history     
 Negative31,9712.041.51 to 2.742.6 × 10−6.31*
 Positive4,1671.350.71 to 2.56.36 
Age, years     
 < 354,1482.591.23 to 5.471.3 × 10−2Ref
 35-5020,4782.571.83 to 3.594.0 × 10−8.17
 50-6531,7362.361.80 to 3.106.5 ×10−105.3 × 10−2
 > 6514,5911.400.93 to 2.12.111.8 × 10−2
ER status     
 Negative39,8501.320.93 to 1.88.12Ref
 Positive52,9392.552.10 to 3.104.9 × 10−219.9 × 10−6
PR status     
 Negative40,0411.721.29 to 2.301.9 × 10−4Ref
 Positive46,6482.512.02 to 3.127.6 × 10−171.7 × 10−2
HER2 status     
 Negative37,9202.401.88 to 3.061.4 × 10−2Ref
 Positive29,5842.661.77 to 4.002.7 × 10−6.73
Negative family history by age category, years     
 < 359673.360.58 to 19.62.18Ref§
 35-508,1812.771.45 to 5.292.0 × 10−3.20
 50-6515,5442.061.33 to 3.191.0 × 10−39.0 × 10−3
 > 657,1011.260.67 to 2.37.472.1 × 10−2
ER-negative by age category, years     
 < 352,8553.020.93 to 9.866.7 × 10−2Ref
 35-5011,0631.460.77 to 2.75.25.62
 50-6517,7391.480.85 to 2.57.17.74
 > 657,8260.960.36 to 2.53.93.53
ER-positive by age category, years     
 < 353,2623.261.05 to 10.184.2 × 10−2Ref¶
 35-5014,0293.122.13 to 4.585.3 × 10−9.20
 50-6524,0292.732.02 to 3.706.7 × 10−118.2 × 10−2
 > 6511,5971.581.01 to 2.494.6 × 10−23.2 × 10−2
NOTE. All models were adjusted for study and age, except the models that included age as a categorical variable, which were only adjusted for study.
Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; OR, odds ratio; PR, progesterone receptor; Ref, reference category.
*
P value of interaction term of family history and CHEK2 in case-control analysis.
Trend test for interaction by including categorical age as a continuous variable in the model P = .014.
Insufficient data to derive family history–positive estimates.
§
Idem P = .004.
Idem P = .66.
Idem P = .026.
The relative risk of breast cancer for CHEK2*1100delC carriers significantly decreased with age for overall (P = .014 for trend) and for ER-positive disease (P = .026 for trend; Table 3; Appendix Fig A3). Smoothed age-specific ORs in years were derived by using a linear CHEK2 × age interaction from a case-only analysis (Fig 2). There was no evidence for a quadratic (CHEK2 × age2) term, which indicated that these models were a reasonable fit (data not shown). ORs decreased by age for ER-positive disease (OR, 0.86 per decade; P = .001) but not for ER-negative disease (OR, 0.93; P = .60). Estimated cumulative risks for ER-positive and ER-negative tumors by age 80 of CHEK2*1100delC carriers were 20% and 3%, respectively, compared with 9% and 2%, respectively, in the general population of the United Kingdom (Fig 3).
Fig 3. Cumulative breast cancer risks for CHEK2*1100delC carriers and the general female population by attained age. ER, estrogen receptor.

Discussion

On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69). The relative risk estimates were consistent across studies, which indicates that the above estimate should be broadly applicable to European women.
Consistent with previous reports,12 the relative risk for ER-negative breast cancer was markedly lower compared with ER-positive breast cancer (OR, 1.32 versus 2.55, respectively; P = 9.9 × 10−6), and the ER-negative risk estimate was not statistically significant. We found neither evidence that risk varied by PR or HER2 status, after adjustment for ER status, nor any evidence for variation in relative risk by grade or morphology.
Previous studies have obtained somewhat higher relative breast cancer risk estimates for CHEK2*1100delC carriers. In particular, in a previous publication that was based on a subset of BCAC studies (25,571 patients with breast cancers and 30,056 controls) and that focused on survival in CHEK2*1100delC carriers, higher risk estimates were found compared with our study (overall OR, 3.01 [95% CI, 2.53 to 3.58]; ER-positive OR, 3.47 [95% CI, 2.87 to 4.18]; and ER-negative OR, 1.54 [95% CI, 1.09 to 2.17]).12 However, these estimates were based on fewer data and were biased as the analyses included clinical genetics–based and familial studies. Our estimate is also somewhat lower than the overall estimate in a previously published meta-analysis (OR, 2.7; 95% CI, 2.1 to 3.4)7; however, that meta-analysis also included fewer individuals, and the higher estimate was largely driven by relatively high estimates from only two studies.
The relative risk of breast cancer in our study showed a modest but statistically significant decrease by age for breast cancer overall and for ER-positive disease. Despite the sample size, we had limited power to derive precise, age-specific relative risk estimates at young ages; therefore, to derive more stable, smoothed age-specific relative risks, we applied a method in which we estimated a linear CHEK2 × age interaction term from case-only analysis (Fig 2). On the basis of this model, a woman age 40 years who carries the CHEK2*1100delC mutation has a relative risk of 3.25 to develop an ER-positive breast cancer compared with a noncarrier of the same age, whereas relative risk for a CHEK2*1100delC carrier at age 70 year is 1.87.
Studies on the basis of patients with breast cancer who were recruited through clinical genetic centers can overestimate the relative risk that is attributable to a genetic variant because of an oversampling of patients with a family history of breast cancer. Indeed, we observed a higher relative risk estimate in women from clinical genetic–based and familial studies, which emphasized the fact that population-based studies are required to provide unbiased relative risk estimates. We assumed that the set of studies that we included in the main analyses, which were defined in the BCAC database as hospital- or population-based, provided a sample of patients with breast cancer and controls that was reasonably representative of the general population. The proportion of women with a first-degree family history (16.5%) was consistent with that expected, which suggested that there was little oversampling on the basis of family that could lead to overestimation of relative risk.
Somewhat surprisingly, in the hospital- and population-based studies, the relative risk estimate was higher in women without a first-degree relative with breast cancer compared with the risk of those with family history, but this was not statistically significantly different and disappeared after the exclusion of two studies with outlier results caused by the study definitions that were used. In addition, the risk estimate of 2.04 among women without a family history was also somewhat lower than that of the overall estimate in all studies (2.26), which might indicate some selection of studies for which family history information was available.
We also found that the breast cancer relative risk was lower for incident invasive breast cancers. This finding was somewhat surprising, given that we previously found that CHEK2*1100delC carriers have a poorer survival compared with noncarriers,12 which would predict a higher relative risk for incident than prevalent cancers. This did not seem to be the result of differences in subtype, as the proportion of ER-positive tumors in incident versus prevalent tumors was similar (77.8% v 77.0%). Larger follow-up studies by genotype and tumor subtype might resolve this discrepancy.
Relative risks in Figure 2 and cumulative risks in Figure 3 provide a basis for counseling. Of note, for all groups, the absolute risks, which take into account death before breast cancer diagnosis as a competing event, will be somewhat lower than the cumulative risks. Breast cancer risks attributed to CHEK2*1100delC carriership reported in our results would be sufficient to classify such women in a moderate-risk, but not high-risk, category according to NICE guidelines in the United Kingdom24; however, a more appropriate method for use of these data is to incorporate the estimates into a model that includes the combined effects of CHEK2*1100delC—and other breast cancer susceptibility genes—with a polygenic component that models the effect of other familial factors. This estimation can be accomplished within the framework of the BOADICEA model, in which the effects of susceptibility variants and other familial factors are assumed to combine multiplicatively.25 Such a model can be used to counsel women with a CHEK2*1100delC mutation, with or without a family history.
Prompted by high breast cancer risk in homozygous carriers of CHEK2*1100delC as well as high cumulative risk for female first-degree family members,9,26,27 testing for this mutation has been already introduced in the Netherlands for female family members who have been referred for BRCA1/2 counseling and genetic testing.28 This testing has also been introducted in Germany (R. Schmutzler, personal communication, December 2015) and Poland (A. Jakubowska, personal communication, December 2015), and other countries, such as Australia (G. Chenevix-Trench, personal communication, December 2015), are considering similar steps. Current Dutch guidelines allow CHEK2*1100delC carriers to be upgraded to more intensive surveillance, without downgrading of noncarriers.28 Prophylactic measures are generally only discussed with homozygous carriers.
The current study only provides estimates for the CHEK2*1100delC mutation. No reliable estimates for other protein-truncating variants in CHEK2 are yet available, but it might be reasonable to assume that the relative risk estimates we present for the 1100delC variant can be applied to carriers of other truncating, though not missense, variants. The results presented here provide a rational basis for deciding whether CHEK2 testing should be offered more widely, and for counseling women who are from families in which one or more members have received positive test results about the implications for management.

Acknowledgment

We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians, and administrative staff who have enabled this work to be carried out. Furthermore, several studies wish to acknowledge specific persons or institutions: Australian Breast Cancer Family Study: Maggie Angelakos, Judi Maskiell, Gillian Dite; Amsterdam Breast Cancer Study: the NKI-AVL Medical Registry and the Family Cancer Clinic, Tony van der Velde, Daoud Ait Moha, Roelof Pruntel, Carla van Tiggelen, and Laura van ‘t Veer; British Breast Cancer Study: Eileen Williams, Elaine Ryder-Mills, Kara Sargus; Breast Cancer in Galway Genetic Study: Niall McInerney, Gabrielle Colleran, Andrew Rowan, Angela Jones, Nicola Miller, Michael Kerin; Breast Cancer Study of the University of Heidelberg: Peter Bugert, Medical Faculty Mannheim; Copenhagen General Population Study: staff and participants of the Copenhagen General Population Study, Dorthe Uldall Andersen, Maria Birna Arnadottir, Anne Bank, Dorthe Kjeldgård Hansen; ESTHER Breast Cancer Study: Hartwig Ziegler, Sonja Wolf, Volker Hermann, Christa Stegmaier, Katja Butterbach; German Consortium for Hereditary Breast & Ovarian Cancer: Stefanie Engert, Heide Hellebrand, Sandra Kröber; Gene Environment Interaction and Breast Cancer in Germany (GENICA): the GENICA Network: Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University of Tübingen, Germany [HB, Wing-Yee Lo, Christina Justenhoven], German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) [HB], Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany [Yon-Dschun Ko, Christian Baisch], Institute of Pathology, University of Bonn, Germany [Hans-Peter Fischer], Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany [Ute Hamann], Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany [TB, Beate Pesch, Sylvia Rabstein, Anne Lotz], and Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Germany [Volker Harth]; Genetic Epidemiology Study of Breast Cancer by Age 50: Ursula Eilber; Hannover Breast Cancer Study: Michael Bremer; Helsinki Breast Cancer Study: Carl Blomqvist, Kristiina Aittomäki, Sofia Khan and Irja Erkkilä; Hannover-Minsk Breast Cancer Study: Peter Hillemanns, Hans Christiansen, and Johann H. Karstens; Kuopio Breast Cancer Project: Eija Myöhänen, Helena Kemiläinen; Kathleen Cuningham Foundation Consortium for research into Familial Breast Cancer (KConFab)/Australian Ovarian Cancer Study: all kCOnFab authors, and Heather Thorne, Eveline Niedermayr, all the KConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the Clinical Follow Up Study; Leuven Multidisciplinary Breast Centre: Gilian Peuteman, Dominiek Smeets, Thomas Van Brussel, Kathleen Corthouts; Memorial Sloan Kettering Cancer Center Study: Marina Corines, Lauren Jacobs; Ontario Familial Breast Cancer Registry: Teresa Selander, Nayana Weerasooriya; Leiden University Medical Centre Breast Cancer Study: E. Krol-Warmerdam, J. Blom, J. Molenaar, MD; NCI Polish Breast Cancer Study: Louise Brinton, Mark Sherman, Neonila Szeszenia-Dabrowska, Beata Peplonska, Witold Zatonski, Pei Chao, Michael Stagner; Rotterdam Breast Cancer Study: Petra Bos, Jannet Blom, Ellen Crepin, Elisabeth Huijskens, Annette Heemskerk, the Erasmus MC Family Cancer Clinic; Singapore and Sweden Breast Cancer Study: the Swedish Medical Research Counsel; Sheffield Breast Cancer Study: Sue Higham, Helen Cramp, Ian Brock, Sabapathy Balasubramanian, Malcolm Reed, Dan Connley; Study of Epidemiology and Risk factors in Cancer Heredity (SEARCH): the SEARCH and EPIC teams; and UCI Breast Cancer Study: Irene Masunaka.
Written on behalf of Norwegian Breast Cancer Study Investigators.
Supported by NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, United Kingdom (to E.J.S.). G.C.-T. is supported by the NHMRC. Supported by (for Breast Cancer Association Consortium) Cancer Research UK [C1287/A10118, C1287/A12014] and by the European Community’s Seventh Framework Programme under grant agreement number 223175 (Grant No. HEALTH-F2-2009-223175; COGS); The Australian Breast Cancer Family Study (ABCFS) was supported by Grant No. UM1 CA164920 from the National Cancer Institute, the National Health and Medical Research Council of Australia, the New South Wales Cancer Council, the Victorian Health Promotion Foundation (Australia), and the Victorian Breast Cancer Research Consortium; the Amsterdam Breast Cancer Study was supported by the Dutch Cancer Society (Grants No. NKI 2007-3839; 2009 4363), BBMRI-NL, which is a Research Infrastructure financed by the Dutch government (NWO 184.021.007), and the Dutch National Genomics Initiative; the Bavarian Breast Cancer Cases and Controls was partly funded by ELAN-Fond of the University Hospital of Erlangen; the British Breast Cancer Study is funded by Cancer Research UK and Breast Cancer Now and acknowledges NHS funding to the NIHR Biomedical Research Centre and the National Cancer Research Network; the Breast Cancer Study of the University of Heidelberg was supported by the Dietmar-Hopp Foundation, the Helmholtz Society, and the German Cancer Research Center (DKFZ); the Copenhagen General Population Study was supported by the Chief Physician Johan Boserup and Lise Boserup Fund, the Danish Medical Research Council, and Herlev Hospital; the ESTHER Breast Cancer Study was supported by a grant from the Baden Württemberg Ministry of Science, Research and Arts; the German Consortium for Hereditary Breast & Ovarian Cancer is supported by the German Cancer Aid (Grant No. 110837); the Gene Environment Interaction and Breast Cancer in Germany study was funded by the Federal Ministry of Education and Research Germany Grants No. 01KW9975/5, 01KW9976/8, 01KW9977/0, and 01KW0114, the Robert Bosch Foundation, Stuttgart, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, the Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, as well as the Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany; the Genetic Epidemiology Study of Breast Cancer by Age 50 was supported by the Deutsche Krebshilfe e. V. [70492] and the German Cancer Research Center (DKFZ); the Hannover Breast Cancer Study was supported by an intramural grant from Hannover Medical School; the Helsinki Breast Cancer Study was financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (266528), the Finnish Cancer Society, The Nordic Cancer Union, and the Sigrid Juselius Foundation; the Hannover-Minsk Breast Cancer Study was supported by a grant from the Friends of Hannover Medical School and by the Rudolf Bartling Foundation; the Hannover-Ufa Breast Cancer Study was supported by a grant from the German Federal Ministry of Research and Education (RUS08/017); the Karolinska Breast Cancer Study was supported by the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet, the Swedish Cancer Society, The Gustav V Jubilee Foundation, and and Bert von Kantzows Foundation; the Kuopio Breast Cancer Project was supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, and by the strategic funding of the University of Eastern Finland; the Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer is supported by a grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council (NHMRC), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, and the Cancer Foundation of Western Australia; the Australian Ovarian Cancer Study was supported by the United States Army Medical Research and Materiel Command [DAMD17-01-1-0729], Cancer Council Victoria, Queensland Cancer Fund, Cancer Council New South Wales, Cancer Council South Australia, The Cancer Foundation of Western Australia, Cancer Council Tasmania, and the National Health and Medical Research Council of Australia (NHMRC; 400413, 400281, 199600); the Mayo Clinic Breast Cancer Study was supported by NIH Grants No. CA192393, CA116167, CA176785, an NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201], the Breast Cancer Research Foundation, and a generous gift from the David F. and Margaret T. Grohne Family Foundation; the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria and was further supported by Australian NHMRC Grants No. 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria; the Memorial Sloan Kettering Cancer Center Study is supported by grants from the Breast Cancer Research Foundation and Robert and Kate Niehaus Clinical Cancer Genetics Initiative; the Norwegian Breast Cancer Study has received funding from the K.G. Jebsen Centre for Breast Cancer Research, the Research Council of Norway grant 193387/V50 (to V.K.) and Grant No. 193387/H10 (to V.K.), South Eastern Norway Health Authority (Grant No. 39346), and the Norwegian Cancer Society (to V.K.); the Northern California Breast Cancer Family Registry was supported by Grant No. UM1 CA164920 from the National Cancer Institute; the Ontario Familial Breast Cancer Registry was supported by Grant No. UM1 CA164920 from the National Cancer Institute; the Leiden University Medical Centre Breast Cancer Study study was supported by the Dutch Cancer Society (RUL 1997-1505) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL CP16); the NCI Polish Breast Cancer Study was funded by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services; the Rotterdam Breast Cancer Study was funded by the Dutch Cancer Society (Grants No. DDHK 2004-3124, DDHK 2009-4318); the Singapore and Sweden Breast Cancer Study study was supported the Agency for Science, Technology and Research of Singapore (A*STAR), the National Institutes of Health, and the Susan G. Komen Breast Cancer Foundation; the Sheffield Breast Cancer Study was supported by Yorkshire Cancer Research S295, S299, S305PA, and Sheffield Experimental Cancer Medicine Centre; the Study of Epidemiology and Risk factors in Cancer Heredity is funded by a programme grant from Cancer Research UK (C490/A10124) and supported by the UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge; the IHCC-Szczecin Breast Cancer Study was supported by Grant No. PBZ_KBN_122/P05/2004; the UCI Breast Cancer Study component of this research was supported by the NIH (Grants No. CA58860, CA92044) and the Lon V Smith Foundation (LVS39420); the UK Breakthrough Generations Study is funded by Breast Cancer Now and the Institute of Cancer Research, London; the US Three State Study was supported by Massachusetts (Grant No. R01CA47305), Wisconsin (Grant No. R01 CA47147), and New Hampshire (Grant No. R01CA69664) centers, and Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services; and the Leuven Multidisciplinary Breast Centre is supported by the 'Stichting tegen Kanker' (232-2008 and 196-2010) and core funding to the Wellcome Trust Centre for Human Genetics from the Wellcome Trust (090532/Z/09/Z).
The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the Breast Cancer Family Registry (BCFR), nor does mention of trade names, commercial products, or organizations imply endorsement by the USA Government or the BCFR. The funding sources had no role in study design; collection, analysis, or interpretation of data; writing of the paper; or in decisions related to publication.

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Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers

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Marjanka K. Schmidt

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Frans Hogervorst

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Richard van Hien

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Sten Cornelissen

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Annegien Broeks

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Muriel A. Adank

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Hanne Meijers

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Quinten Waisfisz

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Antoinette Hollestelle

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Mieke Schutte

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Ans van den Ouweland

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Maartje Hooning

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Irene L. Andrulis

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Natalia N. Antonenkova

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Antonis C. Antoniou

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Marina Bermisheva

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Natalia V. Bogdanova

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Manjeet K. Bolla

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Hermann Brenner

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Thomas Brüning

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Barbara Burwinkel

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Jenny Chang-Claude

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Georgia Chenevix-Trench

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Fergus J. Couch

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Angela Cox

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Simon S. Cross

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Kamila Czene

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Alison M. Dunning

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Peter A. Fasching

Honoraria: Novartis, Amgen, Pfizer, Celgene, Roche, Genomic Health, NanoString Technologies
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Speakers' Bureau: Novartis, Celgene, Pfizer, Roche, Amgen
Research Funding: Novartis (Inst), Amgen (Inst), Celgene (Inst), Pfizer (Inst), Siemens (Inst)

Jonine Figueroa

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Olivia Fletcher

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Henrik Flyger

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Montserrat García-Closas

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Graham G. Giles

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Lothar Haeberle

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Per Hall

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Peter Hillemanns

Honoraria: Roche, SPMSD, Hologic, Abbott Laboratories
Research Funding: GlaxoSmithKline (Inst), Vaccibody (Inst)

John L. Hopper

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Anna Jakubowska

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Esther M. John

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Michael Jones

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Elza Khusnutdinov

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Julia A. Knight

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Veli-Matti Kosma

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Vessela Kristensen

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Andrew Lee

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Annika Lindblom

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Jan Lubinski

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Arto Mannermaa

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Sara Margolin

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Alfons Meindl

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Roger L. Milne

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Taru A. Muranen

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Polly A. Newcomb

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Kenneth Offit

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Tjoung-Won Park-Simon

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Julian Peto

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Paul D.P. Pharoah

Consulting or Advisory Role: Check4Cancer (I)
Patents, Royalties, Other Intellectual Property: Patent on seven SNP breast cancer risk test

Mark Robson

Honoraria: AstraZeneca
Consulting or Advisory Role: Bayer, Pfizer, McKesson
Research Funding: AstraZeneca (Inst), AbbVie (Inst), Myriad Genetics (Inst), Medivation (Inst)
Travel, Accommodations, Expenses: AstraZeneca, Biomarin

Anja Rudolph

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Elinor J. Sawyer

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Rita K. Schmutzler

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Julie Soens

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Anthony Swerdlow

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Rob A.E.M. Tollenaar

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Ian Tomlinson

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Amy Trentham-Dietz

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Celine Vachon

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Qin Wang

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Alice S. Whittemore

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Argyrios Ziogas

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Lizet van der Kolk

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Heli Nevanlinna

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Thilo Dörk

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Stig Bojesen

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Douglas F. Easton

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Appendix

Fig A1. Data flowchart of inclusion and exclusion of patients with breast cancer and healthy controls from the Breast Cancer Association Consortium (BCAC) database.
Fig A2. Forest plot of odds ratios (ORs) from a fixed meta-analysis of the association between CHEK2*1100delC and invasive breast cancer by study, using population- and hospital-based studies. ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HMBCS, Hannover-Minsk Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; LMBC, Leuven Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; OFBCR, Ontario Familial Breast Cancer Registry; PBCS, NCI Polish Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
Fig A3. CHEK2*1100delC-associated breast cancer risk per age category: all invasive and invasive estrogen receptor (ER)–positive disease. P-value trend for all and ER+ disease: P = .014 and P = .026, respectively (see Table 3).
Table A1. Study Information, Number of CHEK2*1100delC Genotyped European Women, and Genotyping Assays Used in Each Study
StudyStudy NameCountryStudy DesignCHEK2*1100delCTotal, No.Type of assay if different from the custom Taqman, No.
Noncarrier, No.Heterozygous Carrier, No.Homozygous Carrier, No.*
ABCFSAustralian Breast Cancer Family StudyAustraliaPopulation-based case-control study2,086702,093Older Taqman assay: 143
ABCS(-F)Amsterdam Breast Cancer StudyNetherlandsHospital-based consecutive cases; population-based controls; substudy ABCS-F: patients with breast cancer recruited through the clinical genetic center3,31710963,432Sanger sequencing: 20
BBCCBavarian Breast Cancer Cases and ControlsGermanyHospital-based cases; population-based controls1,5781301,591 
BBCSBritish Breast Cancer StudyUnited KingdomEnglish and Scottish Cancer Registries: all patients with breast cancer who developed a first primary age < 65 in 1971 or later and who subsequently developed a second primary cancer; patients with unilateral breast cancer diagnosed age < 70 in 1971 or later2,5622802,590Older Taqman assay: 568
BIGGSBreast Cancer in Galway Genetic StudyIrelandHospital-based cases; population based-controls1,825301,828 
BSUCHBreast Cancer Study of the University of HeidelbergGermanyHospital-based cases; healthy blood donator controls1,9622301,985 
CGPSCopenhagen General Population StudyDenmarkConsecutive, incident cases from one hospital with centralized care for a population of 400,000 women from 2001 to present8,6708008,750Older Taqman assay: 12
ESTHERESTHER Breast Cancer StudyGermanyStatewide recruitment of breast cancer cases in all hospitals in Saarland/Germany in 2001-200399150996 
GC-HBOCGerman Consortium for Hereditary Breast & Ovarian CancerGermanyPopulation-based familial case-control study1,9362001,956 
GENICAGene Environment Interaction and Breast Cancer in GermanyGermanyPopulation-based case-control study2,0051802,023 
GESBCGenetic Epidemiology Study of Breast Cancer by Age 50GermanyPopulation-based case-control study1,194301,197Older Taqman assay: 1,197
HABCSHannover Breast Cancer StudyGermanyHospital-based case-control study2,0262702,053Older Taqman assay: 36
HEBCSHelsinki Breast Cancer StudyFinlandHospital-based case-control study and additional familial cases3,38310013,484Older Taqman assay: 36
HMBCSHannover-Minsk Breast Cancer StudyBelarusHospital-based cases; population-based controls2,8111502,826Older Taqman assay: 10
HUBCSHannover-Ufa Breast Cancer StudyRussiaHospital-based cases; population-based controls2,393502,398Older Taqman assay: 16
KARBACKarolinska Breast Cancer StudySwedenPopulation and hospital-based cases; geographically matched controls1,6621601,678 
KBCPKuopio Breast Cancer ProjectFinlandPopulation-based prospective clinical cohort888180906Older Taqman assay: 906
KConFab/AOCSKathleen Cuningham Foundation Consortium for research into Familial Breast Cancer/Australian Ovarian Cancer StudyAustralia and New ZealandClinic-based recruitment of familial patients with breast cancer (cases); population-based case-control study of ovarian cancer (controls only)1,5391301,552iPLEX: 1,552
LMBCLeuven Multidisciplinary Breast CentreBelgiumHospital-based case-control study1,7851401,799 
MCBCSMayo Clinic Breast Cancer StudyUnited StatesHospital-based case-control study2,3712522,398 
MCCSMelbourne Collaborative Cohort StudyAustraliaPopulation-based prospective cohort study1,029701,036 
MSKCCMemorial Sloan Kettering Cancer Center StudyUnited StatesCase-control study94720949 
NBCSNorwegian Breast Cancer StudyNorwayHospital-based case-control study3,4832503,508 
NC-BCFRNorthern California Breast Cancer Family RegistryUnited StatesPopulation-based familial case-control study531100541 
OFBCROntario Familial Breast Cancer RegistryCanadaPopulation-based familial case-control study1,5351111,547 
ORIGOLeiden University Medical Centre Breast Cancer StudyNetherlandsHospital-based prospective cohort study1,1183601,154Oligohybridization assay: 1,154
PBCSNCI Polish Breast Cancer StudyPolandPopulation-based case-control study4,3061704,323 
RBCSRotterdam Breast Cancer StudyNetherlandsHospital based case-control study, Rotterdam area1,5195541,578Oligohybridization assay: 13
SASBACSingapore and Sweden Breast Cancer StudySwedenPopulation-based case-control study2,5182012,539 
SBCSSheffield Breast Cancer StudyUnited KingdomHospital-based case-control study1,9681501,983 
SEARCHStudy of Epidemiology and Risk factors in Cancer HeredityUnited KingdomPopulation-based case-control study14,021131014,152Older Taqman assay: 1,170
SZBCSIHCC-Szczecin Breast Cancer StudyPolandHospital based case-control study1,737601,743 
UCIBCSUCI Breast Cancer StudyUnited StatesPopulation-based case-control study1,4071301,420 
UKBGSUK Breakthrough Generations StudyUnited KingdomPopulation-based cohort study4,6754004,715 
US3SSUS Three State StudyUnited StatesPopulation-based case-control study2,424002,424 
Total   90,2029301591,147Other assay total: 6,833
*
Homozygous CHEK2*1100delC carriers were combined with heterozygous carriers for subsequent Appendix Tables.
Number of samples genotyped only with the specified assay. See the Data Supplement.
Excluded from further analyses, except for estimation of country rates, because of fewer than three CHEK2*1100delC carriers identified.
Table A2. Included Numbers and Proportions of CHEK2*1100delC Carriers in Controls and Patients With Breast Cancer
StudyControlsPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
No. of Non-CHEK2No. of CHEK2*1110delC% CHEK2*1110delCNo. of Non-CHEK2No. of CHEK2*1110delC% CHEK2*1110delCNo. of Non-CHEK2No. of CHEK2*1110delC% CHEK2*1110delC
ABCFS72910.11,35760.4   
ABCS96680.81,375493.4976585.6
BBCC74360.883570.8   
BBCS1,27890.7   1,284191.5
BIGGS*877 0.094830.3   
BSUCH92920.21,033212.0   
CGPS6,171420.72,499381.5   
ESTHER*505 0.048651.0   
GC-HBOC1,10460.5   832141.7
GENICA1,00450.51,001131.3   
GESBC63410.256020.4   
HABCS986101.01,040171.6   
HEBCS1,080151.41,800532.9503336.2
HMBCS1,01350.51,798100.6   
HUBCS1,46410.192940.4   
KARBAC86310.146361.333692.6
KBCP44151.1447132.8   
KConFab93650.5   60381.3
LMBC93720.2848121.4   
MCBCS1,11470.61,257201.6   
MCCS37230.865740.6   
NBCS1,86790.51,616161.0   
NC-BCFR15310.6   37892.3
OFBCR34310.318731.61,00580.8
ORIGO*86 0.01,032363.4   
PBCS2,26360.32,043110.5   
RBCS78891.1   731506.4
SASBAC1,34890.71,170121.0   
SBCS98680.898270.7   
SEARCH7,100380.56,921931.3   
SZBCS85120.288640.4   
UCIBCS50151.090680.9   
UKBGS2,332110.52,343291.2   
Total42,7642330.537,4195021.36,6482083.0
Abbreviations: ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BBCS, British Breast Cancer Study; BIGGS, Breast Cancer in Galway Genetic Study; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; ESTHER, ESTHER Breast Cancer Study; GC-HBOC, German Consortium for Hereditary Breast & Ovarian Cancer; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HMBCS, Hannover-Minsk Breast Cancer Study; HUBCS, Hannover-Ufa Breast Cancer Study; KARBAC, Karolinska Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; KConFab, Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer; LMBC, Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; NC-BCFR, Northern California Breast Cancer Family Registry; OFBCR, Ontario Familial Breast Cancer Registry; ORIGO, Leiden University Medical Centre Breast Cancer Study; PBCS, NCI Polish Breast Cancer Study; RBCS, Rotterdam Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; SZBCS, IHCC-Szczecin Breast Cancer Study; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
*
Included only in case-only analyses.
Table A3. Age of Controls at Interview and of Patients With Breast Cancer at Diagnosis
StudyControlsPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
No.MeanSDNo. MissingNo.MeanSDNo. MissingNo.MeanSDNo. Missing
ABCFS73041.59.6 1,36342.39.2     
ABCS97437.18.0 1,42442.45.1 1,03244.610.32
BBCC74959.612.5 84254.711.7     
BBCS1,28751.49.8     1,30354.48.6 
BIGGS6863.614.580993152.811.520    
BSUCH93156.79.8 86954.612.2185    
CGPS6,21355.312.6 2,53761.312.6     
ESTHER50562.37.1 49060.88.61    
GC-HBOC1,11045.614.5     83646.010.910
GENICA1,00958.211.1 1,01458.111.2     
GESBC63542.75.7 56242.95.9     
HABCS99333.712.631,05757.411.8     
HEBCS1,09541.213.4 1,85357.512.0 53652.712.0 
HMBCS1,01641.612.221,80848.912.3     
HUBCS1,02545.712.944092652.310.87    
KARBAC*   86446960.612.0 34254.112.13
KBCP44653.310.9 45958.814.21    
KConFab94158.011.3     61144.99.5 
LMBC93543.69.5481555.912.545    
MCBCS1,12158.812.0 1,27757.312.3     
MCCS37555.19.0 66161.59.0     
NBCS1,84256.210.2341,54555.512.287    
NC-BCFR15456.94.3     38754.97.4 
OFBCR34456.96.3 19055.96.8 1,01353.010.4 
ORIGO*   861,06853.710.9     
PBCS2,26955.810.0 2,05455.89.9     
RBCS*   797    78144.410.0 
SASBAC1,35763.36.4 1,18263.16.5     
SBCS99457.65.7 98959.412.2     
SEARCH7,13657.99.127,01353.29.01    
SZBCS85358.411.0 89055.911.3     
UCIBCS50654.912.2 91459.312.9     
UKBGS2,34358.29.4 2,37251.29.4     
Total39,95653.812.73,04137,57454.511.83476,84149.611.015
NOTE. This table includes all breast cancers irrespective of tumor behavior.
Abbreviations: ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BBCS, British Breast Cancer Study; BIGGS, Breast Cancer in Galway Genetic Study; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; ESTHER, ESTHER Breast Cancer Study; GC-HBOC, German Consortium for Hereditary Breast & Ovarian Cancer; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HMBCS, Hannover-Minsk Breast Cancer Study; HUBCS, Hannover-Ufa Breast Cancer Study; KARBAC, Karolinska Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; KConFab, Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer; LMBC, Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; NC-BCFR, Northern California Breast Cancer Family Registry; OFBCR, Ontario Familial Breast Cancer Registry; ORIGO, Leiden University Medical Centre Breast Cancer Study; PBCS, NCI Polish Breast Cancer Study; RBCS, Rotterdam Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; SZBCS, IHCC-Szczecin Breast Cancer Study; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
*
Included only in case-only analyses.
Table A4. Behavior of Breast Tumors
StudyPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
No.*% Invasive% In SituNo. MissingNo.*% Invasive% In SituNo. Missing
ABCFS1,363100.0      
ABCS1,42499.90.1 1,03491.78.3 
BBCC84294.45.6     
BBCS    1,303100.0  
BIGGS95194.55.5     
BSUCH1,05498.21.8     
CGPS2,53796.63.4     
ESTHER48999.01.02    
GC-HBOC    846100.0  
GENICA1,014100.0      
GESBC55693.96.16    
HABCS1,05798.51.5     
HEBCS1,85393.26.8 53695.05.0 
HMBCS1,80899.90.1     
HUBCS93399.90.1     
KARBAC469100.0  345100.0  
KBCP46092.08.0     
KConFab    53877.722.373
LMBC86098.51.5     
MCBCS1,27784.815.2     
MCCS661100.0      
NBCS1,58499.80.248    
NC-BCFR    38769.330.8 
OFBCR190100.0  1,01398.31.7 
ORIGO1,06491.58.64    
PBCS1,96893.66.486    
RBCS    78093.66.41
SASBAC1,182100.0      
SBCS95692.47.633    
SEARCH7,01498.02.0     
SZBCS73295.14.9158    
UCIBCS91485.514.6     
UKBGS2,36796.63.45    
Total37,57996.53.53426,78293.86.274
Abbreviations: ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BBCS, British Breast Cancer Study; BIGGS, Breast Cancer in Galway Genetic Study; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; ESTHER, ESTHER Breast Cancer Study; GC-HBOC, German Consortium for Hereditary Breast & Ovarian Cancer; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HMBCS, Hannover-Minsk Breast Cancer Study; HUBCS, Hannover-Ufa Breast Cancer Study; KARBAC, Karolinska Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; KConFab, Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer; LMBC, Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; NC-BCFR, Northern California Breast Cancer Family Registry; OFBCR, Ontario Familial Breast Cancer Registry; ORIGO, Leiden University Medical Centre Breast Cancer Study; PBCS, NCI Polish Breast Cancer Study; RBCS, Rotterdam Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; SZBCS, IHCC-Szczecin Breast Cancer Study; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
*
Number with data available.
This study has fewer than five in situ breast cancers and was excluded from in situ–only analyses.
Table A5. Receptor Status of Invasive Breast Tumors From Population- and Hospital-Based Breast Cancer Studies
StudyERPRHER2
No.*Negative, %Positive, %No.*Negative, %Positive, %No.*Negative, %Positive, %
ABCFS1,16834.565.51,16430.869.2   
ABCS93634.665.488048.551.589874.825.2
BBCC74429.370.774134.765.354083.316.7
BIGGS70224.975.155624.675.444779.220.8
BSUCH70025.174.969934.565.566682.417.6
CGPS1,75815.184.91,26736.263.872084.915.1
ESTHER42123.876.341533.566.519272.427.6
GENICA98822.078.098529.870.370770.929.1
GESBC44337.063.043839.760.3   
HABCS81215.684.479219.680.4   
HEBCS1,69418.281.81,69434.865.291684.715.3
HMBCS4630.469.6      
HUBCS20244.155.920243.156.919149.750.3
KARBAC44016.883.238524.475.6   
KBCP38922.677.438838.161.937687.212.8
LMBC78816.283.878323.176.970584.415.6
MCBCS1,07716.383.81,07625.674.480885.015.0
MCCS61823.376.762134.865.258782.117.9
NBCS1,31427.972.21,28641.658.463188.012.0
OFBCR17625.075.017534.965.1   
ORIGO66926.873.252942.257.8   
PBCS1,67633.866.21,67047.053.01,20382.517.5
SASBAC82118.082.079928.471.6   
SBCS54022.677.423839.960.125092.08.0
SEARCH5,27020.279.82,81528.571.52,32788.611.4
SZBCS65728.271.819560.539.553283.816.2
UCIBCS65120.080.064230.469.6   
UKBGS425.075.0333.366.7250.050.0
Total25,70423.376.721,43833.966.112,69882.917.1
Abbreviations: ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BBCS, British Breast Cancer Study; BIGGS, Breast Cancer in Galway Genetic Study; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; ER, estrogen receptor; ESTHER, ESTHER Breast Cancer Study; GC-HBOC, German Consortium for Hereditary Breast & Ovarian Cancer; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HER2, human epidermal growth factor receptor 2; HMBCS, Hannover-Minsk Breast Cancer Study; HUBCS, Hannover-Ufa Breast Cancer Study; KARBAC, Karolinska Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; KConFab, Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer; LMBC, Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; NC-BCFR, Northern California Breast Cancer Family Registry; OFBCR, Ontario Familial Breast Cancer Registry; ORIGO, Leiden University Medical Centre Breast Cancer Study; PBCS, NCI Polish Breast Cancer Study; PR, progesterone receptor; RBCS, Rotterdam Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; SZBCS, IHCC-Szczecin Breast Cancer Study; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
*
Number with data available.
Data from this study were excluded from subtype-specific analyses adjusted for study.
Table A6. Family History of Controls and Patients With Breast Cancer
StudyControlsPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
No.*No Relative, %At Least One Relative, %No.*No Relative, %At Least One Relative, %No.*No Relative, %At Least One Relative, %
ABCFS73093.36.71,36382.417.6   
ABCS      76050.749.3
BBCC57784.415.678785.514.5   
BBCS97993.26.8   1,30285.914.1
BIGGS   30662.137.9   
BSUCH   28786.413.6   
CGPS   2,10280.219.8   
ESTHER41689.410.643882.917.1   
GENICA1,00991.98.11,01485.414.6   
GESBC63594.06.056288.111.9   
HABCS   1,02483.816.2   
HEBCS   1,84976.823.25363.596.5
HMBCS   5094.06.0   
HUBCS61798.71.390793.86.2   
KARBAC   46183.716.332022.577.5
KBCP44695.14.946088.711.3   
KConFab74089.510.5   52614.485.6
LMBC   76081.218.8   
MCBCS99081.718.31,18878.521.5   
NBCS1,02190.89.24278.621.4   
NC-BCFR15485.114.9   38735.164.9
OFBCR34186.213.818993.16.91,01353.146.9
ORIGO   89183.716.3   
PBCS2,26994.25.82,05389.410.6   
RBCS      78146.953.1
SASBAC1,23390.39.71,15284.615.4   
SBCS99489.710.398985.814.2   
SEARCH4,91993.36.76,86883.916.1   
SZBCS853100.0 89089.410.6   
UCIBCS46184.215.891373.726.3   
UKBGS§4100.0 1994.75.3   
Total19,38891.98.127,56483.516.55,62548.251.8
NOTE. Relatives are first-degree relatives with breast cancer. This table includes all breast cancers irrespective of tumor behavior.
Abbreviations: ABCFS, Australian Breast Cancer Family Study; ABCS, Amsterdam Breast Cancer Study; BBCC, Bavarian Breast Cancer Cases and Controls; BBCS, British Breast Cancer Study; BIGGS, Breast Cancer in Galway Genetic Study; BSUCH, Breast Cancer Study of the University of Heidelberg; CGPS, Copenhagen General Population Study; ESTHER, ESTHER Breast Cancer Study; GC-HBOC, German Consortium for Hereditary Breast & Ovarian Cancer; GENICA, Gene Environment Interaction and Breast Cancer in Germany; GESBC, Genetic Epidemiology Study of Breast Cancer by Age 50; HABCS, Hannover Breast Cancer Study; HEBCS, Helsinki Breast Cancer Study; HMBCS, Hannover-Minsk Breast Cancer Study; HUBCS, Hannover-Ufa Breast Cancer Study; KARBAC, Karolinska Breast Cancer Study; KBCP, Kuopio Breast Cancer Project; KConFab, Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer; LMBC, Multidisciplinary Breast Centre; MCBCS, Mayo Clinic Breast Cancer Study; MCCS, Melbourne Collaborative Cohort Study; NBCS, Norwegian Breast Cancer Study; NC-BCFR, Northern California Breast Cancer Family Registry; OFBCR, Ontario Familial Breast Cancer Registry; ORIGO, Leiden University Medical Centre Breast Cancer Study; PBCS, NCI Polish Breast Cancer Study; RBCS, Rotterdam Breast Cancer Study; SASBAC, Singapore and Sweden Breast Cancer Study; SBCS, Sheffield Breast Cancer Study; SEARCH, Study of Epidemiology and Risk factors in Cancer Heredity; SZBCS, IHCC-Szczecin Breast Cancer Study; UCIBCS, UCI Breast Cancer Study; UKBGS, UK Breakthrough Generations Study.
*
Number with data available.
Included only in case-only analyses.
Higher proportion of controls compared with cases, either because of overrepresentation of controls with a family history in the subset genotyped for CHEK2 (BBCC) or because of the case definition used in the analyses (ie, the subset of nonfamilial cases [OFBCR]).
§
Data from this study were excluded from all family history–specific analyses. Of note, there were no data for MCCS and GC-HBOC.
Table A7. Characteristics of Controls and Patients With Breast Cancer by CHEK2*1100delC Carriership
CharacteristicControlsPatients From Population- and Hospital-Based StudiesPatients From Familial or Clinical Genetics Center–Based Studies
Total, No.Non-CHEK2*1100delC, %CHEK2*1100delC, %Total, No.Non-CHEK2*1100delC, %CHEK2*1100delC, %Total, No.Non-CHEK2*1100delC, %CHEK2*1100delC, %
Genotyped42,99795.50.537,92198.71.36,85697.03.0
Family history*         
 No17,81099.60.423,02798.81.22,71197.72.3
 Yes1,57898.91.14,53797.92.12,91496.23.8
BRCA1/2 germline mutation         
 No42,99599.50.532,76098.71.36,62596.93.1
 Yes2100 161100 231100.0 
Age, years         
 < 353,26799.30.71,39998.41.662895.94.1
 35-5010,41899.40.612,00498.51.52,79796.93.1
 50-6518,30499.50.516,39898.81.22,82497.32.7
 > 657,96799.40.67,76598.91.158598.11.9
 All39,95699.40.637,56698.71.36,83497.12.9
Tumor behavior         
 Invasive   36,26498.71.36,36396.93.1
 In situ   1,31597.82.241997.62.4
Morphology         
 Ductal   22,75098.61.43,50496.63.4
 Lobular   4,34998.81.252298.31.7
 Medullary   40699.01.053100.04.8
 Mixed   1,09698.61.412695.22.4
 Mucinous   37298.71.356100.04.7
 Other   1,30799.20.857297.6 
 Papillary   7798.71.312100.0 
 Tubular   37299.70.310795.3 
Grade         
 I   5,31898.81.261197.22.8
 II   12,44098.61.41,29395.94.1
 III   8,08398.81.21,16696.73.3
ER         
 Negative   6,17099.20.865298.21.8
 Positive   20,14498.41.61,88795.84.2
PR         
 Negative   7,45098.81.183697.42.6
 Positive   14,44798.51.51,54295.84.2
HER2         
 Negative   10,65398.61.456093.96.1
 Positive   2,23198.61.411396.53.5
NOTE. This table shows all available data, without study adjustment, for each of the variables shown, and includes homozygous carriers.
Abbreviations: ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; PR, progesterone receptor.
*
Family history: no, none; or yes, at least one first-degree relative with breast cancer.
BRCA1/2 mutation status was only available for a subset of samples, all unknowns are assumed to be noncarriers.
Table A8. Breast Cancer Risk Estimates of CHEK2*1100delC Carriers Using Different Models
ModelTotal, No.OR95% CIPP *
Carrier model     
 All patients with breast cancer81,7112.482.11 to 2.907.2 × 10−29.03
 Population- and hospital-based patients with breast cancer72,5012.361.99 to 2.805.6 × 10−23.02
Log additive model     
 All breast patients with cancer81,7112.472.11 to 2.903.7 × 10−29.15
 Population- and hospital-based patients with breast cancer72,5012.361.99 to 2.802.1 × 10−23.10
Saturated model     
 All breast patients with cancer81,7112.442.08 to 2.876.3 × 10−28 
 Population- and hospital-based patients with breast cancer72,5012.321.95 to 2.755.5 × 10−22 
Carrier model; excluding homozygous CHEK2 carriers     
 All patients with breast cancer81,7002.442.08 to 2.876.3 × 10−28 
 Population- and hospital-based patients with breast cancer72,4932.321.95 to 2.755.5 × 10−22 
NOTE. Carrier model: CHEK2 was included as 0 = noncarrier or 1 = carriers; log-additive model, CHEK2 was included as 0 = noncarriers, 1 = heterozygous CHEK2, 2 = homozygous CHEK2; saturated model: CHEK2 was modeled using offset as explained in Patients and Methods.
Abbreviation: OR, odds ratio.
*
P value of the model concerned versus the saturated model.

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Information

Published In

Journal of Clinical Oncology
Pages: 2750 - 2760
PubMed: 27269948

History

Published online: June 06, 2016
Published in print: August 10, 2016

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Affiliations

Marjanka K. Schmidt [email protected]
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Frans Hogervorst
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Richard van Hien
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Sten Cornelissen
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Annegien Broeks
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Muriel A. Adank
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Hanne Meijers
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Quinten Waisfisz
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Antoinette Hollestelle
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Mieke Schutte
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Ans van den Ouweland
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Maartje Hooning
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Irene L. Andrulis
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Hoda Anton-Culver
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Natalia N. Antonenkova
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Antonis C. Antoniou
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Volker Arndt
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Marina Bermisheva
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Natalia V. Bogdanova
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Manjeet K. Bolla
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Hiltrud Brauch
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Hermann Brenner
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Thomas Brüning
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Barbara Burwinkel
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Jenny Chang-Claude
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Georgia Chenevix-Trench
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Fergus J. Couch
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Angela Cox
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Simon S. Cross
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Kamila Czene
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Alison M. Dunning
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Peter A. Fasching
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Jonine Figueroa
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Olivia Fletcher
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Henrik Flyger
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Eva Galle
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Montserrat García-Closas
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Graham G. Giles
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Lothar Haeberle
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Per Hall
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Peter Hillemanns
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
John L. Hopper
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Anna Jakubowska
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Esther M. John
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Michael Jones
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Elza Khusnutdinova
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Julia A. Knight
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Veli-Matti Kosma
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Vessela Kristensen
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Andrew Lee
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Annika Lindblom
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Jan Lubinski
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Arto Mannermaa
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Sara Margolin
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Alfons Meindl
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Roger L. Milne
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Taru A. Muranen
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Polly A. Newcomb
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Kenneth Offit
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Tjoung-Won Park-Simon
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Julian Peto
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Paul D.P. Pharoah
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Mark Robson
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Anja Rudolph
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Elinor J. Sawyer
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Rita K. Schmutzler
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Caroline Seynaeve
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Julie Soens
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Melissa C. Southey
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Amanda B. Spurdle
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Harald Surowy
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Anthony Swerdlow
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Rob A.E.M. Tollenaar
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Ian Tomlinson
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Amy Trentham-Dietz
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Celine Vachon
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Qin Wang
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Alice S. Whittemore
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Argyrios Ziogas
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Lizet van der Kolk
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Heli Nevanlinna
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Thilo Dörk
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Stig Bojesen
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.
Douglas F. Easton
Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, and Lizet van der Kolk, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital; Muriel A. Adank, Hanne Meijers, and Quinten Waisfisz, VU University Medical Center, Amsterdam; Antoinette Hollestelle, Mieke Schutte, Maartje Hooning, and Caroline Seynaeve, Erasmus MC Cancer Institute; Ans van den Ouweland, Erasmus University Medical Center, Rotterdam; Rob A.E.M. Tollenaar, Leiden University Medical Center, Leiden, the Netherlands; Irene L. Andrulis and Julia A. Knight, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Irene L. Andrulis and Julia A. Knight, University of Toronto, Toronto, Ontario, Canada; Hoda Anton-Culver and Argyrios Ziogas, University of California, Irvine; Peter A. Fasching, David Geffen School of Medicine, University of California, Los Angeles; Esther M. John, Cancer Prevention Institute of California, Fremont; Esther M. John, Alice S. Whittemore, Stanford University School of Medicine, Stanford, CA; Natalia N. Antonenkova, N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus; Antonis C. Antoniou, Manjeet K. Bolla, Andrew Lee, Alison M. Dunning, Paul D.P. Pharoah, Qin Wang, and Douglas F. Easton, University of Cambridge, Cambridge; Angela Cox and Simon S. Cross, University of Sheffield, Sheffield; Olivia Fletcher, Michael Jones, and Anthony Swerdlow, The Institute of Cancer Research; Julian Peto, London School of Hygiene and Tropical Medicine; Elinor J. Sawyer, King's College London, London; Jonine Figueroa, University of Edinburgh Medical School, Edinburgh; Ian Tomlinson, University of Oxford, Oxford, United Kingdom; Volker Arndt, Hiltrud Brauch, Hermann Brenner, Barbara Burwinkel, Jenny Chang-Claude, Anja Rudolph, Harold Surowy, German Cancer Research Center; Barbara Burwinkel and Harald Surowy, University of Heidelberg, Heidelberg; Natalia V. Bogdanova, Peter Hillemanns, Tjoung-Won Park-Simon, and Thilo Dörk, Hannover Medical School, Hannover; Hiltrud Brauch, Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart; Hiltrud Brauch, University of Tübingen, Tübingen; Thomas Brüning, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum; Jenny Chang-Claude, University Medical Center Hamburg-Eppendorf, Hamburg; Peter A. Fasching and Lothar Haeberle, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen; Alfons Meindl, Technische Universität München, Munich; Rita K. Schmutzler, University Hospital of Cologne; Rita K. Schmutzler, University of Cologne, Cologne, Germany; Marina Bermisheva, Ufa Scientific Center of Russian Academy of Sciences; Elza Khusnutdinova, Bashkir State University, Ufa, Russia; Georgia Chenevix-Trench and Amanda B. Spurdle, QIMR Berghofer Medical Research Institute, Brisbane; Graham G. Giles and Roger L. Milne, Cancer Council Victoria; Graham G. Giles, John L. Hopper, Roger L. Milne, and Melissa C. Southey, The University of Melbourne, Melbourne, Australia; Fergus J. Couch and Celine Vachon, Mayo Clinic, Rochester, MN; Kamila Czene, Per Hall, Annika Lindblom, and Sara Margolin, Karolinska Institutet, Stockholm, Sweden; Jonine Figueroa, Montserrat García-Closas, National Cancer Institute, Rockville, MD; Henrik Flyger and Stig Bojesen, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev; Stig Bojesen, University of Copenhagen, Copenhagen, Denmark; Eva Galle, University of Leuven; Eva Galle, Vesalius Research Center; Julie Soens, University Hospital Gasthuisberg, Leuven, Belgium; Anna Jakubowska and Jan Lubinski, Pomeranian Medical University, Szczecin, Poland; Veli-Matti Kosma and Arto Mannermaa, University of Eastern Finland; Veli-Matti Kosma and Arto Mannermaa, Kuopio University Hospital, Kuopio; Taru A. Muranen and Heli Nevanlinna, University of Helsinki, Helsinki, Finland; Vessela Kristensen, Oslo University Hospital Radiumhospitalet; Vessela Kristensen, University of Oslo, Oslo, Norway; Polly A. Newcomb and Amy Trentham-Dietz, University of Wisconsin, Madison, WI; Polly A. Newcomb, Fred Hutchinson Cancer Research Center, Seattle, WA; and Kenneth Offit, Mark Robson, Memorial Sloan Kettering Cancer Center, New York, NY.

Notes

Corresponding author: Marjanka K. Schmidt, MD, Division of Molecular Pathology, and Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands; e-mail: [email protected].

Author Contributions

Conception and design: Marjanka K. Schmidt, Douglas F. Easton
Financial support: Marjanka K. Schmidt, Frans Hogervorst
Administrative support: Marjanka K. Schmidt, Manjeet K. Bolla, Qin Wang
Provision of study materials or patients: Marjanka K. Schmidt, Frans Hogervorst, Muriel A. Adank, Hanne Meijers, Quinten Waisfisz, Antoinette Hollestelle, Mieke Schutte, Ans van den Ouweland, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Marina Bermisheva, Natalia V. Bogdanova, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G. Giles, Lothar Haeberle, Per Hall, Peter Hillemanns, John L. Hopper, Anna Jakubowska, Esther M. John, Michael Jones, Elza Khusnutdinov, Julia A. Knight, Veli-Matti Kosma, Vessela Kristensen, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Sara Margolin, Alfons Meindl, Roger L. Milne, Taru A. Muranen, Polly A. Newcomb, Kenneth Offit, Tjoung-Won Park-Simon, Julian Peto, Paul D.P. Pharoah, Mark Robson, Anja Rudolph, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Julie Soens, Melissa C. Southey, Rob A.E.M. Tollenaar, Ian Tomlinson, Amy Trentham-Dietz, Celine Vachon, Alice S. Whittemore, Argyrios Ziogas, Lizet van der Kolk, Heli Nevanlinna, Thilo Dörk, Stig Bojesen
Collection and assembly of data: Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, Muriel A. Adank, Hanne Meijers, Quinten Waisfisz, Antoinette Hollestelle, Mieke Schutte, Ans van den Ouweland, Maartje Hooning, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Marina Bermisheva, Natalia V. Bogdanova, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G. Giles, Lothar Haeberle, Per Hall, Peter Hillemanns, John L. Hopper, Anna Jakubowska, Esther M. John, Michael Jones, Elza Khusnutdinov, Julia A. Knight, Veli-Matti Kosma, Vessela Kristensen, Andrew Lee, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Sara Margolin, Alfons Meindl, Roger L. Milne, Taru A. Muranen, Polly A. Newcomb, Kenneth Offit, Tjoung-Won Park-Simon, Julian Peto, Paul D.P. Pharoah, Mark Robson, Anja Rudolph, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Julie Soens, Melissa C. Southey, Amanda B. Spurdle, Harald Surowy, Anthony Swerdlow, Rob A.E.M. Tollenaar, Ian Tomlinson, Amy Trentham-Dietz, Celine Vachon, Qin Wang, Alice S. Whittemore, Argyrios Ziogas, Lizet van der Kolk, Heli Nevanlinna, Thilo Dörk, Stig Bojesen, Douglas F. Easton
Data analysis and interpretation: Marjanka K. Schmidt, Antonis C. Antoniou, Stig Bojesen, Douglas F. Easton
Manuscript writing: All authors
Final approval of manuscript: All authors

Disclosures

Authors’ disclosures of potential conflicts of interest are found in the article online at www.jco.org. Author contributions are found at the end of this article.

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Marjanka K. Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, Muriel A. Adank, Hanne Meijers, Quinten Waisfisz, Antoinette Hollestelle, Mieke Schutte, Ans van den Ouweland, Maartje Hooning, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Antonis C. Antoniou, Volker Arndt, Marina Bermisheva, Natalia V. Bogdanova, Manjeet K. Bolla, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, Alison M. Dunning, Peter A. Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G. Giles, Lothar Haeberle, Per Hall, Peter Hillemanns, John L. Hopper, Anna Jakubowska, Esther M. John, Michael Jones, Elza Khusnutdinova, Julia A. Knight, Veli-Matti Kosma, Vessela Kristensen, Andrew Lee, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Sara Margolin, Alfons Meindl, Roger L. Milne, Taru A. Muranen, Polly A. Newcomb, Kenneth Offit, Tjoung-Won Park-Simon, Julian Peto, Paul D.P. Pharoah, Mark Robson, Anja Rudolph, Elinor J. Sawyer, Rita K. Schmutzler, Caroline Seynaeve, Julie Soens, Melissa C. Southey, Amanda B. Spurdle, Harald Surowy, Anthony Swerdlow, Rob A.E.M. Tollenaar, Ian Tomlinson, Amy Trentham-Dietz, Celine Vachon, Qin Wang, Alice S. Whittemore, Argyrios Ziogas, Lizet van der Kolk, Heli Nevanlinna, Thilo Dörk, Stig Bojesen, Douglas F. Easton
Journal of Clinical Oncology 2016 34:23, 2750-2760

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